Most human studies of CBD have been done on people who have seizures, and the FDA recently approved the first CBD-based drug, Epidiolex, for rare forms of epilepsy. Clinical trials for other conditions are promising, but tiny. In one Brazilian study published in 2011 of people with generalized social anxiety disorder, for example, taking a 600-mg dose of CBD (higher than a typical dose from a tincture) lessened discomfort more than a placebo, but only a dozen people were given the pill.
It’s thought that CBD might affect your health by attaching to receptors in the body’s endocannabinoid system—a complex biological system involved in maintaining certain aspects of your health. Emerging research shows that endocannabinoids may play a role in regulating such functions as memory, sleep, and mood, as well as metabolic processes like energy balance. In addition, CBD oil may play a role in improving a variety of health conditions.
If you live in a state where CBD is legal for your condition, it’s best to buy it from a state-regulated dispensary. But even there, oversight is uneven. “I feel safe being a cannabis consumer in Colorado, since the state tracks everything from seed to sale, but I didn’t the first few years after cannabis became legal,” when the rules were still taking shape, says Robyn Griggs Lawrence, the Boulder author of The Cannabis Kitchen Cookbook, which features recipes for cannabis edibles.
Now, scientific research is discovering why. Evidence from laboratory studies and clinical studies, have begun to reveal the mechanisms through which CBD helps control seizures. But, unlike most other conditions that CBD has been shown to treat, the FDA has actually agreed that the evidence is conclusive enough that CBD is now an approved medication for epilepsy for humans.
Buying online is less reliable still because there’s no regulation or standardization. What you see on the label may not be what you are getting. A 2017 study in JAMA found that of the 84 CBD products researchers bought online, 43 percent had more CBD than indicated, while 26 percent had less, and some had unexpected THC.“There’s a 75 percent chance of getting a product where the CBD is mislabeled,” says Marcu, one of the study’s coauthors.
Hemp oil does have a number of uses and is often marketed as a cooking oil or a product that is good for moisturizing the skin. It is also used in the production of certain soaps, shampoos, and foods. It is also a basic ingredient for bio-fuel and even a more sustainable form of plastic. Hemp has been cultivated and used for roughly 10,000 years, and it definitely has useful purposes. However, a lack of cannabinoids, namely CBD, means that it has little therapeutic value.

Dr. Cohen has found that chronic conditions including autoimmune diseases and pain syndromes can be helped with a 6-mg under-the-tongue tincture (the fastest delivery system) or a 25-mg capsule taken twice a day. Dosages for topical products like lotions are especially hard to determine—there’s no clarity on how much CBD gets into the system through the skin.


CBD’s wellness applications reach far and wide, and some people look to it to save their skin from dehydration and stress. The light and airy Healthworx Rescue Butter comes to the rescue with mango butter, raspberry seed oil, cranberry seed oil, English poppy seed oil, and kokum butter. It’s strong enough to moisturize cracked hands and feet, while still being gentle enough for some of your more delicate areas. Remember, though, it’s for external use only!
However, when compared to skin-care pillar ingredients like retinols and vitamin C, the research behind CBD's efficacy in skin care (especially beyond the realms of being a temporary topical pain reliever) is still relatively in its infancy. "There is limited data to suggest that CBD may decrease oil production when applied topically," says Joshua Zeichner, director of cosmetic and clinical research at Mount Sinai Hospital, who explains that unlike marijuana, which contains psychoactive THC, hemp seed oil is a common source of naturally anti-inflammatory cannabinoids — which is what ends up in all of those lotions and potions. "Hemp seed oil also acts as an emollient to smooth rough cells on the skin's surface and offers moisturizing benefits," he adds.
Buying online is less reliable still because there’s no regulation or standardization. What you see on the label may not be what you are getting. A 2017 study in JAMA found that of the 84 CBD products researchers bought online, 43 percent had more CBD than indicated, while 26 percent had less, and some had unexpected THC.“There’s a 75 percent chance of getting a product where the CBD is mislabeled,” says Marcu, one of the study’s coauthors.
Because they can’t. In most states, veterinarians risk losing their licenses if they recommend cannabinoids for pets. That may start to change soon though. Colorado is leading the charge in this, as in so many cannabinoid-related issues. And legislation is in the works in both New York and California that would allow veterinarians to legally discuss the use of cannabis products with their clients.
This content is strictly the opinion of Dr. Josh Axe and is for informational and educational purposes only. It is not intended to provide medical advice or to take the place of medical advice or treatment from a personal physician. All readers/viewers of this content are advised to consult their doctors or qualified health professionals regarding specific health questions. Neither Dr. Axe nor the publisher of this content takes responsibility for possible health consequences of any person or persons reading or following the information in this educational content. All viewers of this content, especially those taking prescription or over-the-counter medications, should consult their physicians before beginning any nutrition, supplement or lifestyle program.
CBD oil is not legal everywhere. It is banned/restricted by countries such as UAE, Dubai, and Saudi Arabia. Although CBD oil is illegal in many of the US states too, some have legalized its use for medicinal purposes. While the number would be ever-changing, as of 2016 there are 17 states in the US which have legalized the use of low THC, high CBD products for medical reasons in limited situations. These states include Alabama, Georgia, Iowa, Kentucky, Florida, Mississippi, Louisiana, Missouri, North Carolina, Oklahoma, South Carolina, Wisconsin, Wyoming, Tennessee, Texas, Utah, and Virginia. It is advisable to consult your local health specialist before use.
Because CBD works with specific neurotransmitters to reduce anxiety and increase the ability to focus, initial studies have shown promise in its ability to increase the quality of life by decreasing the symptoms of ADHD for many sufferers. Much of this research is still in the early phases (with a lot of room to learn more), however, CBD may be worth adding to a daily routine for those frustrated with traditional treatment options.
Recent studies – in addition to new medication options that include CBD – have also shown promising results in various forms of epilepsy, including Dravet Syndrome. In summary findings published by the U.S. National Library of medicine, multiple small clinical trials have shown that CBD is able to reduce the number of seizures and severity of seizures for those that experience specific forms of epilepsy on a regular basis. (9)
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